Definitive Criteria for Ambiguous Lineage Leukemias

Biphenotypic, bilineal, ambiguous or mixed lineage: strange leukemias!

Acute leukemias of ambiguous origin.

OBJECTIVES This session of the Society for Hematopathology/European Association for Haematopathology Workshop focused on acute leukemias of ambiguous origin. METHODS We provide an overview of mixed-phenotype acute leukemia (MPAL) as recognized in the current World Health Organization classification and summarize diagnostic criteria for major categories of MPAL: B/myeloid, T/myeloid, B/T, and ...

Two Cases of Near-Tetraploidy in Acute Leukemias of Ambiguous Lineage

Acute leukemia of ambiguous lineage (ALAL) is a rare subtype of acute leukemias that does not show any clear evidence of differentiation along a single lineage [1]. Although both numerical and structural chromosomal abnormalities are commonly associated with acute and chronic hematologic malignancies, near-tetraploidy has been reported rarely (1.2% of AML cases) [2, 3]. Adult AML patients with ...

MicroRNA profiling can classify acute leukemias of ambiguous 1 lineage as either acute myeloid leukemia or acute lymphoid 2 leukemia

MicroRNA profiling can classify acute leukemias of ambiguous 1 lineage as either acute myeloid leukemia or acute lymphoid 2 leukemia. 3 4 David C. de Leeuw, Willemijn van den Ancker, Fedor Denkers, Renée X. de Menezes, 5 Theresia M. Westers , Gert J. Ossenkoppele , Arjan A. van de Loosdrecht 1 and Linda 6 Smit . 7 8 Authors’ Affiliation: 9 1 Department of Hematology, VU University Medical Cente...

MicroRNA profiling can classify acute leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemia.

PURPOSE Classification of acute leukemia is based on the commitment of leukemic cells to the myeloid or the lymphoid lineage. However, a small percentage of acute leukemia cases lack straightforward immunophenotypical lineage commitment. These leukemias of ambiguous lineage represent a heterogeneous category of acute leukemia that cannot be classified as either acute myeloid leukemia (AML) or a...